Listar por autor "Ausín, Karina"
Mostrando ítems 1-14 de 14
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Amyotrophic lateral sclerosis is accompanied by protein derangements in the olfactory bulb-tract axis
Lachén Montes, Mercedes
; Mendizuri, Naroa; Ausín, Karina; Andrés Benito, Pol; Ferrer, Isidro; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2020)
Artículo / Artikulua 
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive muscle paralysis due to the degeneration of upper and lower motor neurons. Recent studies point out an involvement of the non-motor axis ... -
Brain IGF-I regulates LTP, spatial memory, and sexual dimorphic behavior
Herrero-Labrador, Raquel; Fernández Irigoyen, Joaquín ; Vecino, Rebeca; González-Arias, Canela; Ausín, Karina; Crespo, Inmaculada; Fernández Acosta, Francisco J.; Nieto-Estévez, Vanesa; Román, M. José; Perea, Gertrudis; Torres-Alemán, Ignacio; Santamaría, Enrique; Vicario, Carlos (Life Science Alliance, 2023)
Artículo / Artikulua
Insulin-like growth factor-I (IGF-I) exerts multiple actions, yet the role of IGF-I from different sources is poorly understood. Here, we explored the functional and behavioral consequences of the conditional deletion of ... -
Deregulated transcription and proteostasis in adult mapt knockout mouse
Andrés Benito, Pol; Flores, África; Busquet-Areny, Sara; Carmona, Margarita; Ausín, Karina; Cartas Cejudo, Paz; Lachén Montes, Mercedes ; Río, José Antonio del; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Ferrer, Isidro (MDPI, 2023)
Artículo / Artikulua
Transcriptomics and phosphoproteomics were carried out in the cerebral cortex of B6.Cg-Mapttm1(EGFP)Klt (tau knockout: tau-KO) and wild-type (WT) 12 month-old mice to learn about the effects of tau ablation. Compared with ... -
Dysregulated protein phosphorylation: a determining condition in the continuum of brain aging and Alzheimer's disease
Ferrer, Isidro; Andrés Benito, Pol; Ausín, Karina; Pamplona, Reinald; Río, José Antonio del; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Wiley, 2021)
Artículo / Artikulua
Tau hyperphosphorylation is the first step of neurofibrillary tangle (NFT) formation. In the present study, samples of the entorhinal cortex (EC) and frontal cortex area 8 (FC) of cases with NFT pathology classified as ... -
Early-onset molecular derangements in the olfactory bulb of Tg2576 mice: novel insights into the stress-responsive olfactory kinase dynamics in Alzheimer’s disease
Lachén Montes, Mercedes ; González Morales, Andrea ; Palomino Alonso, Maialen; Ausín, Karina; Gómez-Ochoa, Marta; Zelaya Huerta, María Victoria ; Ferrer, Isidro; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Frontiers Media, 2019)
Artículo / Artikulua
The olfactory bulb (OB) is the first processing station in the olfactory pathway. Despite smell impairment, which is considered an early event in Alzheimer’s disease (AD), little is known about the initial molecular ... -
Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy
Ferrer, Isidro; Andrés Benito, Pol; Zelaya Huerta, María Victoria ; Erro Aguirre, María Elena; Carmona, Margarita; Ausín, Karina; Lachén Montes, Mercedes ; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Río, José Antonio del (Springer, 2020)
Artículo / Artikulua
Globular glial tauopathy (GGT) is a progressive neurodegenerative disease involving the grey matter and white matter (WM) and characterized by neuronal deposition of hyper-phosphorylated, abnormally conformed, truncated, ... -
Mass spectrometry-based proteomic profiling of thrombotic material obtained by endovascular thrombectomy in patients with ischemic stroke
Muñoz, Roberto; Santamaría, Enrique; Rubio, Idoya; Ausín, Karina; Labarga, Alberto (MDPI, 2018)
Artículo / Artikulua
Thrombotic material retrieved from acute ischemic stroke (AIS) patients represents a valuable source of biological information. In this study, we have developed a clinical proteomics workflow to characterize the protein ... -
Metabolic dyshomeostasis induced by SARS-CoV-2 structural proteins reveals immunological insights into viral olfactory interactions
Lachén Montes, Mercedes; Mendizuri, Naroa; Ausín, Karina; Echaide Górriz, Míriam; Blanco, Ester; Chocarro, Luisa ; Toro, María de; Escors Murugarren, David; Fernández Irigoyen, Joaquín ; Kochan, Grazyna; Santamaría, Enrique (Frontiers Media, 2022)
Artículo / Artikulua
One of the most common symptoms in COVID-19 is a sudden loss of smell. SARS-CoV-2 has been detected in the olfactory bulb (OB) from animal models and sporadically in COVID-19 patients. To decipher the specific role over ... -
Network-driven proteogenomics unveils an aging-related imbalance in the olfactory IκBα-NFκB p65 complex functionality in Tg2576 Alzheimer’s disease mouse model
Palomino Alonso, Maialen; Lachén Montes, Mercedes ; González Morales, Andrea ; Ausín, Karina; Pérez Mediavilla, Alberto; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (MDPI, 2017)
Artículo / Artikulua
Olfaction is often deregulated in Alzheimer’s disease (AD) patients, and is also impaired in transgenic Tg2576 AD mice, which overexpress the Swedish mutated form of human amyloid precursor protein (APP). However, little ... -
Neuroanatomical quantitative proteomics reveals common pathogenic biological routes between amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD)
Iridoy Zulet, Marina; Zubiri, Irene; Zelaya Huerta, María Victoria ; Martínez, Leire; Ausín, Karina; Lachén Montes, Mercedes ; Santamaría, Enrique; Fernández Irigoyen, Joaquín ; Jericó Pascual, Ivonne (MDPI, 2019)
Artículo / Artikulua
(1) Background: Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are neurodegenerative disorders with an overlap in clinical presentation and neuropathology. Common and differential mechanisms leading ... -
Oleuropein-driven reprogramming of the myeloid cell compartment to sensitise tumours to PD-1/PD-L1 blockade strategies
Blanco, Ester; Silva-Pilipich, Noelia; Bocanegra Gondán, Ana Isabel; Chocarro, Luisa ; Procopio, Antonio; Ausín, Karina; Fernández Irigoyen, Joaquín ; Fernández Rubio, Leticia; Razquin, Nerea; Igea, Ana; Garnica, Maider; Echaide Górriz, Míriam; Arasanz Esteban, Hugo; Vera García, Ruth; Escors Murugarren, David; Smerdou, Cristian; Kochan, Grazyna (Springer Nature, 2024)
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Background: Previous studies have shown that functional systemic immunity is required for the efficacy of PD-1/PD-L1 blockade immunotherapies in cancer. Hence, systemic reprogramming of immunosuppressive dysfunctional ... -
Olfactory bulb neuroproteomics reveals a chronological perturbation of survival routes and a disruption of prohibitin complex during Alzheimer's disease progression
Lachén Montes, Mercedes ; González Morales, Andrea ; Zelaya Huerta, María Victoria ; Pérez Valderrama, Estela; Ausín, Karina; Ferrer, Isidro; Fernández Irigoyen, Joaquín ; Santamaría, Enrique (Springer Nature, 2017)
Artículo / Artikulua
Olfactory dysfunction is among the earliest features of Alzheimer’s disease (AD). Although neuropathological abnormalities have been detected in the olfactory bulb (OB), little is known about its dynamic biology. Here, OB- ... -
A proteomic atlas of lineage and cancer-polarized expression modules in myeloid cells modeling immunosuppressive tumor-infiltrating subsets
Blanco, Ester; Ibáñez-Vea, María ; Hernández, Carlos; Drici, Lylia; Martínez de Morentin Iribarren, Xabier; Gato Cañas, María; Ausín, Karina; Bocanegra Gondán, Ana Isabel; Zuazo Ibarra, Miren ; Chocarro, Luisa ; Arasanz Esteban, Hugo; Fernández Hinojal, Gonzalo; Fernández Irigoyen, Joaquín ; Smerdou, Cristian; Garnica, Maider; Echaide Górriz, Míriam; Fernández Rubio, Leticia; Morente Sancho, Pilar; Ramos-Castellanos, Pablo; Llopiz, Diana; Santamaría, Enrique; Larsen, Martin R.; Escors Murugarren, David; Kochan, Grazyna (MDPI, 2021)
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Monocytic and granulocytic myeloid-derived suppressor cells together with tumor-infiltrating macrophages constitute the main tumor-infiltrating immunosuppressive myeloid populations. Due to the phenotypic resemblance to ... -
Smelling the dark proteome: functional characterization of PITH domain-containing protein 1 (C1orf128) in olfactory metabolism
Lachén Montes, Mercedes ; Mendizuri, Naroa; Ausín, Karina; Pérez Mediavilla, Alberto; Azkargorta, Mikel; Fernández Irigoyen, Joaquín ; Santamaría, Enrique; Iloro, Ibon; Elortza, Félix; Kondo, Hiroyuki; Ohigashi, Izumi; Ferrer, Isidro; Torre, Rafael de la; Robledo, Patricia (ACS Publications, 2020)
Artículo / Artikulua
The Human Proteome Project (HPP) consortium aims to functionally characterize the dark proteome. On the basis of the relevance of olfaction in early neurodegeneration, we have analyzed the dark proteome using data mining ...
